1. Natural negative regulator of muscle growth, inhibiting satellite cell activation and muscle fiber hypertrophy
Gene knockout animal experiments show a 200-300% increase in muscle mass (Nature 1997)
2. Metabolic balance effect
Regulates adipocyte differentiation and inhibits white fat accumulation
Improves insulin sensitivity (muscle glucose uptake ↑35%)
3. Disease treatment targets
Core intervention targets for sarcopenia and muscular dystrophy (such as Duchenne muscular dystrophy)
Anti-tumor application: inhibits cachexia muscle loss
GDF-8-Core advantages
✅ 1. Muscle hyperplasia potential
Inhibitors can break through genetic limitations on muscle mass (clinical trials show lean body mass + 4.5kg/12 weeks)
✅ 2. Metabolic disease applications
The only target that simultaneously improves muscle + fat + blood sugar (excellent data for Phase II diabetes)
✅ 3. Anti-aging breakthrough
Reversal of age-related sarcopenia (60 years old + subjects’ grip strength ↑28%)
✅ 4. Medical-grade safety
Monoclonal antibody drugs (such as Domagrozumab) have entered Phase III clinical trials
✅ 5. Precision intervention
Local injection can target specific muscle groups (different from systemic steroids-)