RAD140, also known as testosterone, is an orally bioavailable non-steroidal selective androgen receptor modulator (SARM) that can increase muscle mass and enhance the effect of testosterone without causing the adverse side effects of anabolic steroids.
Early studies and user reviews show that it has better results and fewer side effects than using steroids, making it one of the most exciting and powerful SArms to date. Keep reading to fully understand all the information you need to know about RAD140, including its benefits, side effects, research and results on increasing muscle mass and maintaining gains.
The history of RAD140
RAD140 is currently being developed by the pharmaceutical company Radius. Its initial discovery was initially published in 2010, which meant that the research was limited. However, initial research, company reports and anecdotal user reviews are very promising for building muscle without the side effects of anabolic steroids.
Through the internal discovery program, it was found that Testolone is actually being developed for the treatment of breast cancer and muscle atrophy in postmenopausal women. According to the company’s website, the FDA accepted their investigational new drug application, and the first human clinical trial is expected to begin in 2017.
How does the RAD140 work
Androgen receptors (AR) mainly target normal human sexual development, but their activation through compounds (such as testosterone) also affects bones, muscles, the liver and the central nervous system.
The problem within the medical and bodybuilding communities is that using testosterone to activate AR signals to increase muscle and bone development can also affect sexual tissues, leading to testicular atrophy, enlarged clitoris in women, and even a higher risk of prostate cancer.
RAD140, a non-steroidal selective androgen receptor modulator (SARM), bypasses this problem. Due to the way RAD140 binds to androgen receptors, different cells respond by releasing different proteins, and only some androgen receptors are activated throughout the body.
This stimulation leads to the activation of androgen receptors in bone and muscle cells rather than enhancing liver enzymes or affecting sexual tissues.
According to Radius, a pharmaceutical company based in Cambridge:
“… The potent, oral bioavailable and non-steroidal RAD140 is designed to make hormone receptors in body tissues act as if they have received a good dose of testosterone, triggering the same effects as progens and anabolic steroids minus unwanted side effects…
The benefits of RAD140
Eight main benefits were observed in both the initial study and the comments reported by users.
RAD140 helps increase muscle mass
The primary benefit of supplementing RAD140 is that it can increase lean tissue without adding fat. In fact, in the initial research conducted on monkeys, scientists observed that their average weight increased by more than 10% within just 28 days. This is only carried out using RAD140 and has no adverse side effects traditionally associated with testosterone.
2. The RAD140 can enhance speed, endurance and stamina during high-intensity training
Do you want to exercise longer, harder and achieve better results every time you go to the gym? When using Testolone supplements, it is common to increase speed, endurance and endurance reports during exercise. In addition, due to its ability to increase muscle tissue and reduce fat, it can optimize high-intensity training and interval training every time.
3.RAD140 has a stronger anabolic effect than testosterone
Similar to other SArms, such as LGD4033 (Ligandrol) or S4 (Andarine), RAD140 produces results similar to testosterone but without side effects.
RAD140 interacts with hormone rece ptors in muscle and bone tissue in the same way as high-dose testosterone, all without the estrogenic side effects caused by anabolic steroids.
Many users on the forum have also reported a greater anabolic effect than testosterone and are sometimes used as PCT for steroid users to retain muscle mass between cycles.
4.RAD140 can reduce the side effects of testosterone
When used in combination with anabolic steroids, preliminary studies have shown that RAD140 reduces the side effects of testosterone stimulation on the prostate and seminal vesicles of monkeys [2].
Furthermore, many users of anabolic steroids have reported their concerns about liver health. However, during the 28-day trial period, even if weight was gained in a short period of time (which might cause liver strain), the dose for these monkeys was significantly lower than the 10-fold increase in liver enzymes at the fully effective dose.
Our suggestion?
Since the results of RAD140 have already demonstrated better performance than anabolic steroids, users might as well completely forget about testosterone and stick to using SARM.
Testosterone does not seem to have the side effects of anabolic steroids on the reproductive organs
Preliminary studies on mice have found that a low dose of RAD140 is necessary to stimulate muscle growth without affecting the weight of the prostate.
This means that RAD140 can selectively stimulate the growth of muscles and bones while reducing the impact on sexual tissues such as the prostate or clitoris. Yes, this means that RAD140 is safe for women.
6.RAD140 can help lose weight by increasing fat reduction
RAD140 indirectly reduces body fat by increasing muscle and bone cells. Maintaining the metabolism of muscle and bone cells is more expensive than that of fat cells. By increasing muscle mass, an increase in metabolism can be observed, making it easier to lose weight.
As RAD140 can enhance endurance, endurance and speed during interval training, users can also report increased muscle growth and reduced fat storage.
7.RAD140 is currently on trial for the treatment of breast cancer
RAD140 has been discovered and is currently being developed by the pharmaceutical company Radius specifically for the treatment of androgen receptor (AR) and estrogen receptor positive (ER+) breast cancer in postmenopausal women.
In vitro studies completed in 2017 indicated that RAD140 inhibited the growth of AR/ER+ breast cancer cells. The results of these studies support further research on RAD140 as a treatment for breast cancer and have proposed the first human clinical trial.
RAD140 is believed to have a neuroprotective effect on brain health in patients with neurodegenerative diseases
As men’s testosterone levels decline, the risk of diseases in androgen-reactive tissues, including the brain, increases, which indicates the development of neurodegenerative diseases such as Alzheimer’s disease.
However, treating AR disease with testosterone may increase the risk of prostate cancer. Recent studies have shown that RAD140 may be as effective as testosterone in reducing cell death and has no side effects on the prostate.
Side effects of RAD140
Like most SArms, studies have shown that RAD140 does not seem to have any of the common side effects of steroid compounds. Unlike testosterone, RAD140 does not cause an enlarged prostate or testicular contraction.
However, since it is still in the early stage of development, this does not mean there are no long-term effects. Some users reported side effects including headache or insomnia, which disappeared at the correct dose.
Post time: Jun-13-2025