New progress has been made in electrochemical peptide modification: On May 11th, the research team led by Professor Zhixiong Ruan and Associate Professor Xinwei Hu from Guangzhou Medical University published a study on the efficient regioselective diazide modification of dehydroalanine peptides catalyzed by manganese in Advanced Science. This reactive group has excellent tolerance and strong substrate adaptability, with a maximum yield of up to 99%, and can achieve gram-scale synthesis. It provides new means for the modification of complex bioactive molecules, facilitating drug research and development as well as the advancement of green synthetic chemistry.
- Successful Construction of Novel antimicrobial Peptide Nanofibers: According to China Science and Technology News, a team from Northeast Agricultural University recently published in Science Advances their research on constructing multifunctional antimicrobial peptide nanofibers with anti-enzymatic hydrolysis, trapping and killing, and specific targeting capabilities. It developed the antimicrobial peptide Nhar by scanning the side chain length of cationic amino acids, which may solve the problems of feed antimicrobial peptides being prone to inactivation and disrupting the balance of the microbiota.
The breeding of low-yield strains of fermented animal protein peptides has undergone a transformation: According to relevant information, synthetic biology will bring about a change in the breeding of low-yield strains of fermented animal protein peptides in 2025. For instance, the CRISPR-Cas12i superevolution system has an editing efficiency of 98%, which can reduce the generation of sulfides. The integration of metabolic models with AI can reduce the strain screening cycle from 12 months to 45 days. Yeast-bacterial co-fermentation and other methods can enhance peptide purity and shorten the fermentation cycle.
Post time: Aug-21-2025