Antiestrogenic effects
Dromostanolone Propionate is the propionate salt form of dromostanolone, a synthetic anabolic steroid related to dihydrotestosterone that has antiestrogenic effects. Dromostanolone inhibits the growth of estrogen receptor-presenting breast cancers; its virilizing effects limit its clinical usefulness.
Drostanolone propionate is a modified form of drostanolone, where a carboxylic acid ester (propionic acid) has been attached to the 17-beta hydroxyl group. Drostanolone Propionate is a synthetic androgenic anabolic steroid and is approximately 5 times as potent as natural methyltestosterone.
Physiological effect
Like testosterone and other androgenic hormones, dromostanolone binds to the androgen receptor. This causes downstream genetic transcriptional changes. This ultimately causes retention of nitrogen, potassium, and phosphorus; increases protein anabolism; and decreases amino acid catabolism. The antitumour activity of dromostanolone appears related to reduction or competitive inhibition of prolactin receptors or estrogen receptors or production.
Specifically, Masteron is the DHT hormone that has been structurally altered by the addition of a methyl group at the carbon 2 position, This protects the hormone from the metabolic breakdown by the 3-hydroxysteroid dehydrogenase enzyme, which is found in the skeletal muscle.
Description
17b-Hydroxy-2a-methyl-5a-androstan-3-one propionate, also known as drostanolone propionate, is a synthetic anabolic-androgenic steroid. It has similar properties to dihydrotestosterone. It had been used for the treatment of breast cancer in the past. However, it is now mainly used by athletes and bodybuilder as an anabolic steroid. It has two major effects including enhancing the physical/athletic performance (such as endurance and strength) and enhancing physical health (muscle buildup and fat loss). It should be administrated via intramuscular injection instead of oral taking.
Chemical Properties
White Solid
Uses
Drostanolone propionate is the propionate salt form of dromostanolone, a synthetic anabolic steroid related to dihydrotestosterone that has antiestrogenic effects. It is used as an antineoplastic for use in females, for palliation of androgenresponsive recurrent mammary cancer in women who are more than one year but less than five years postmenopausal. Now it is used to help improve athletic performance and muscle gain.
Definition
ChEBI: Drostanolone propionate is a steroid ester and a 3-oxo-5alpha-steroid. It has a role as an antineoplastic agent. It is functionally related to a metholone.
Preparation
Drostanolone propionate is prepared from 9,11-dehydro-17a-methyl-testosterone raw material, reacts with lithium chloride and N-chlorosuccinimide to generate 9a,11-dichloro-17a-methyl- 95 testosterone is further prepared by esterification with propionin.
Post time: Sep-01-2025